Cholera vaccine how does it work




















Science ; —4. New knowledge on pathogenesis of bacterial enteric infections as applied to vaccine development. Microbiol Rev ; 47 — Duration of infection-derived immunity to cholera. J Infect Dis ; — Natural cholera infection-derived immunity in an endemic setting.

J Infect Dis ; —8. Endemic cholera in rural Bangladesh, — Am J Epidemiol ; — Holmgren J, Svennerholm AM. Mechanisms of disease and immunity in cholera: a review. J Infect Dis ; :S— Single-cell analysis of the plasmablast response to Vibrio cholerae demonstrates expansion of cross-reactive memory B cells.

MBio ; 7. Plasma and mucosal immunoglobulin M, immunoglobulin A, and immunoglobulin G responses to the Vibrio cholerae O1 protein immunome in adults with cholera in Bangladesh. Susceptibility to Vibrio cholerae infection in a cohort of household contacts of patients with cholera in Bangladesh.

Memory B cell responses to Vibrio cholerae O1 lipopolysaccharide are associated with protection against infection from household contacts of patients with cholera in Bangladesh. Clin Vaccine Immunol ; 19 —8. Lipopolysaccharide-specific memory B cell responses to an attenuated live cholera vaccine are associated with protection against Vibrio cholerae infection.

Vaccine ; 36 — Immunity of cholera in man: relative role of antibacterial versus antitoxic immunity. Field trial of oral cholera vaccines in Bangladesh: results from three-year follow-up.

Lancet ; —3. Clin Infect Dis ; 62 — Neoh SH, Rowley D. The antigens of Vibrio cholerae involved in the vibriocidal action of antibody and complement. Comparison of immune responses to the O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi adult patients with cholera.

Clin Vaccine Immunol ; 19 — Incomplete correlation of serum vibriocidal antibody titer with protection from Vibrio cholerae infection in urban Bangladesh. Immunity provided by an outer membrane vesicle cholera vaccine is due to O-antigen-specific antibodies inhibiting bacterial motility.

Vaccine ; 34 —6. Mucosal immunologic responses in cholera patients in Bangladesh. Clin Vaccine Immunol ; 18 — Bornside GH. Jaime Ferran and preventive inoculation against cholera. Bull Hist Med ; 55 — Cholera vaccines. J Travel Med ; 8 — Field trial of oral cholera vaccines in Bangladesh: results of one year of follow-up. J Infect Dis ; —9. Field trial of inactivated oral cholera vaccines in Bangladesh: results from 5 years of follow-up. Vaccine ; 14 —6. Field trial of oral cholera vaccines in Bangladesh.

Lancet ; 2 —7. Memory B cell and other immune responses in children receiving two doses of an oral killed cholera vaccine compared to responses following natural cholera infection in Bangladesh. Clin Vaccine Immunol ; 18 —7. Impact of B subunit killed whole-cell and killed whole-cell-only oral vaccines against cholera upon treated diarrhoeal illness and mortality in an area endemic for cholera. Lancet ; 1 —9.

Safety and immunogenicity study of a killed bivalent O1 and O whole-cell oral cholera vaccine Shanchol, in Bangladeshi adults and children as young as 1 year of age. Vaccine ; 29 — The oral cholera vaccine Shanchol when stored at elevated temperatures maintains the safety and immunogenicity profile in Bangladeshi participants. Vaccine ; 34 —8. Lancet Infect Dis ; 13 —6. Oral Cholera Vaccine Working Group of the Global Task Force on Cholera Control Protection against cholera from killed whole-cell oral cholera vaccines: a systematic review and meta-analysis.

Lancet Infect Dis ; 17 —8. Immunogenicity of a killed bivalent O1 and O whole cell oral cholera vaccine, Shanchol, in Haiti. Recommendations of the Advisory Committee on Immunization Practices for use of cholera vaccine. Lancet ; 2 — Randomized, double-blind, placebo-controlled, multicentered trial of the efficacy of a single dose of live oral cholera vaccine CVD HgR in preventing cholera following challenge with Vibrio cholerae O1 El tor inaba three months after vaccination.

Infect Immun ; 67 —5. Suharyono , Simanjuntak C, Witham N, et al. Can oral cholera vaccination play a role in controlling a cholera outbreak? Vaccine ; 22 — Vaccine ; 18 — Harris JB. Editorial commentary: resurrecting a live oral cholera vaccine. Clin Infect Dis ; 62 —7. The high burden of cholera in children: comparison of incidence from endemic areas in Asia and Africa.

Immune responses to the O-specific polysaccharide antigen in children who received a killed oral cholera vaccine compared to responses following natural cholera infection in Bangladesh. Clin Vaccine Immunol ; 20 —8. The Vi conjugate typhoid vaccine is safe, elicits protective levels of IgG anti-Vi, and is compatible with routine infant vaccines.

Clin Vaccine Immunol ; 18 —5. The efficacy of a Salmonella typhi Vi conjugate vaccine in two-to-five-year-old children. N Engl J Med ; —9. Phase 1 evaluation of Vibrio cholerae O1, serotype Inaba, polysaccharide-cholera toxin conjugates in adult volunteers. Infect Immun ; 66 —9. Conjugate vaccines from bacterial antigens by squaric acid chemistry: a closer look. Chembiochem ; 18 — Simple, direct conjugation of bacterial O-SP-core antigens to proteins: development of cholera conjugate vaccines.

Bioconjug Chem ; 22 — Mucosal Immunol ; 11 — The live attenuated cholera vaccine CVD HgR primes responses to the toxin-coregulated pilus antigen TcpA in subjects challenged with wild-type Vibrio cholerae.

Clin Vaccine Immunol ; Karen Wong discusses the risk for cholera in travelers, how it can be prevented, and use of the new vaccine.

Please note: In December , the maker of this cholera vaccine will temporarily stop making and selling it. This vaccine may be in limited supply or unavailable. The Advisory Committee on Immunization Practices ACIP voted to approve the vaccine for adults 18 — 64 years old who are traveling to an area of active cholera transmission.

Cholera vaccines offer incomplete protection. Therefore, vaccination should never take the place of standard prevention and control measures. Skip directly to site content Skip directly to page options Skip directly to A-Z link. The Vaccine Education Center staff regularly reviews materials for accuracy. You should not consider the information in this site to be specific, professional medical advice for your personal health or for your family's personal health.

You should not use it to replace any relationship with a physician or other qualified healthcare professional. For medical concerns, including decisions about vaccinations, medications and other treatments, you should always consult your physician or, in serious cases, seek immediate assistance from emergency personnel. Contact Us Online. The disease What is cholera? What are the symptoms of cholera?

How common is cholera? How do you catch cholera? Where can you catch cholera? How can I protect myself and my family? If you are traveling to a country where cholera is occurring, follow safe food and water precautions: Drink only treated water Do not consume raw or undercooked foods, especially seafood Practice diligent hand washing before eating and after using the bathroom.

Is there a cholera vaccine? How is the cholera vaccine made? Does the cholera vaccine have side effects? People who receive the oral cholera vaccine may experience nausea, vomiting or diarrhea. Why do I need a hepatitis A vaccine, but not a cholera vaccine, given that both can be transmitted in contaminated water and shellfish?

Do the benefits of the cholera vaccine outweigh its risks?



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